Pros and Cons

Different Ketamine Nasal Sprays and Tips on Administration

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The two most common ways to administer ketamine nasal sprays are regular nasal spray bottles and nasal spray atomizers.

Nasal spray bottles malfunction easier than the atomizers. Often the medication can crystallize in the spray tube if not used regularly. The nasal spray bottle is normally included in the cost of the ketamine prescription

Nasal spray atomizers atomizes particles in the saline solution. Nasal spray atomizers are primarily used for different types of sinusitis. Based on observation data from our clinic atomizers are better at delivering medication to the nasal passage with less likelihood of irritation. The average cost for an atomizer is $65 one time purchase and they are normally battery operated. .

We recommend the nasal spray atomizer over the nasal spray bottle to our patients . The atomizers are more expensive initially but in the long run they are more cost effective. The atomizers have increased efficiency in medication delivery.

The most common side effect of ketamine nasal spray is irritated nasal passages. Moisturizing the nostrils plays a big role in reducing irritation of the nasal passage. We recommend the use of a topical cream acetyl glutathione 5% to help with the irritation. The topical cream comes in three different scents, spearmint, menthol and lavender. We recommend spearmint and menthol during the day. Lavender during the night. We partner with University Pharmacy who uses several different bases for these creams. The most common base to these creams is cocoa butter followed by combinations involving cocoa butter. One tube will last most people 2-3 months. Below is a description of what glutathione is and how it helps.


Glutathione is naturally produced in the body. It is important to the immune system and helps remove pollutants from the body. Normal cellular function results in some buildup of free radicals that must be removed with the help of glutathione molecules. In some cases however the number of free radicals becomes greater than the body’s ability to remove them. This can be due to some factor increasing the amount of toxins in the body or to a decrease in levels of GSH.

Ketamine nasal spray dosing. The greater the strength the more likely it will cause irritation to the nasal passage. The strengths that are the most likely to cause irritation are between 125 and 175 mg per ml. Going much over 175 mg per ml will cause the ketamine to fall out of suspension.

The most effective way to use ketamine for depression, anxiety, and panic attacks is 1 spray per nostril then massage the nostril so the mucus membrane absorbs the ketamine and then you do the other nostril the same way. Only sniff up if you feel the medication leaking out of the nose. Wait seven minutes between the two sprays and do a total number of sprays based on the recommendation of your medical provider.